Cheesy Meatball Sub Casserole Recipe

There is something incredibly comforting about a classic sub sandwich, and turning it into a casserole creates a whole new level of cozy, cheesy goodness. This Cheesy Meatball Sub Casserole takes all the best parts of a meatball sub—the savory meatballs, rich marinara, gooey cheeses, and crusty bread—and brings them together into one irresistible baked dish. Whether you’re feeding a crowd or just looking for a hearty weeknight winner, this casserole is pure deliciousness in every bite, with layers of flavor and texture that will have everyone asking for seconds.

Ingredients You’ll Need

Gathering the right ingredients is key to nailing the perfect balance of creaminess, tanginess, and melty cheesiness in this hearty casserole. Each component plays a specific role: the bread adds structure and crunch, the meatballs bring savory richness, and the cheeses create that luscious, golden crust we all love.

• 1 lb fully cooked meatballs (frozen or homemade): The star protein, packed with flavor and ready to go straight into your casserole.
• 1 loaf French bread, cut into thick slices: Provides a sturdy base that soaks up sauce without getting mushy.
• 1 jar (24 oz) marinara or spaghetti sauce: Tangy tomato goodness that keeps everything saucy and flavorful.
• 1/2 cup cream cheese, softened: Adds dreamy creaminess and helps meld all the ingredients together.
• 1/2 cup sour cream: A tangy element that balances the richness of the cheeses perfectly.
• 1 tsp garlic powder: Infuses a subtle garlicky warmth throughout the dish.
• 1/2 tsp Italian seasoning: Brings in herby notes that elevate the marinara and meatballs.
• 2 cups shredded mozzarella cheese: Melted mozzarella is essential for that irresistible gooey texture.
• 1/2 cup grated Parmesan cheese: Offers a nutty, savory kick on top for a beautiful golden finish.
• Fresh parsley or basil (optional for garnish): Adds a pop of green freshness and a lovely aroma to the finished casserole.

How to Make Cheesy Meatball Sub Casserole

Step 1: Prepare Your Oven and Baking Dish

Start by preheating your oven to 375°F (190°C). Lightly grease a 9×13 inch baking dish—this ensures nothing sticks and cleanup is easier.

Step 2: Make the Creamy Base

In a medium bowl, combine the softened cream cheese and sour cream. Add garlic powder and Italian seasoning, then stir until smooth and well blended. This creamy layer will add moisture and a tangy richness that beautifully complements the meatballs and bread.

Step 3: Layer the Casserole

Spread the creamy mixture evenly across the bottom of your prepared baking dish. Next, arrange the thick slices of French bread on top, covering the creamy layer completely. Spread the cooked meatballs evenly over the bread slices for a hearty middle layer. Pour your marinara sauce over the meatballs, making sure they get coated well. Finally, sprinkle mozzarella and Parmesan cheeses generously over everything to create that mouthwatering cheesy crust.

Step 4: Bake to Perfection

Place the casserole uncovered in the oven and bake for 25 to 30 minutes, or until the cheese is melted, bubbly, and golden brown around the edges. This baking step melds all the tempting flavors together and crisps the bread just enough while keeping the center delightfully soft.

Step 5: Rest and Garnish

Once out of the oven, let your Cheesy Meatball Sub Casserole rest for a few minutes. This short wait allows everything to set slightly and makes serving easier. For that final touch of freshness, sprinkle chopped parsley or basil over the top before serving.

How to Serve Cheesy Meatball Sub Casserole

Garnishes

A sprinkle of fresh parsley or basil adds not only a burst of color but a fragrant, herbal brightness that contrasts beautifully with the richness of the casserole. For an extra pop, you could also add a pinch of red pepper flakes or a drizzle of balsamic glaze.

Side Dishes

This casserole is filling on its own, but pairing it with a crisp green salad or steamed veggies balances the meal perfectly. A light Caesar salad or a simple arugula toss with lemon vinaigrette adds freshness, while roasted broccoli or green beans bring a satisfying crunch beside each cheesy, meaty bite.

Creative Ways to Present

If you want to impress guests or brighten up a potluck table, try serving the casserole in colorful bowls or family-style on a rustic wooden board with extra bread slices. You can also offer an assortment of dipping sauces—extra marinara, garlic aioli, or even a spicy pepper sauce—to elevate the experience and let everyone customize their servings.

Make Ahead and Storage

Storing Leftovers

Leftover Cheesy Meatball Sub Casserole keeps beautifully in the fridge for up to 3 days. Cover it tightly with foil or plastic wrap to lock in moisture and prevent it from drying out.

Freezing

This casserole freezes well, making it a great option for meal prep. Assemble the dish but don’t bake it yet—wrap it tightly and freeze for up to 3 months. When ready, bake directly from frozen at 375°F (190°C), adding about 15 minutes to the baking time, until heated through and bubbly.

Reheating

To reheat leftovers, warm individual portions in the microwave for 1-2 minutes or heat the whole casserole in a 350°F (175°C) oven until hot throughout and the cheese is slightly melted again. Covering with foil prevents over-browning while reheating.

FAQs

Can I use homemade meatballs instead of store-bought?

Absolutely! Homemade meatballs bring a lovely personal touch and can be seasoned to your liking. Just make sure they are fully cooked before layering them in the casserole.

Is it possible to make this dish vegetarian?

Yes! Swap the meatballs for plant-based meatballs or hearty roasted vegetables like mushrooms and eggplants to keep the casserole deliciously satisfying without meat.

What type of bread works best for this casserole?

French bread or any sturdy crusty bread is ideal because it holds up well under the sauce without getting soggy. Avoid soft sandwich bread, which can become too mushy.

Can I prepare this casserole ahead of time and bake later?

Definitely. You can assemble all the layers, cover the dish, and refrigerate it for a few hours or overnight before baking. Just add a few extra minutes to the baking time if it’s chilled.

How can I make the casserole extra cheesy?

Feel free to increase the mozzarella or Parmesan in the recipe, or add other gooey cheeses like provolone or fontina. A sprinkle of extra cheese atop before baking gives a decadent finish.

Final Thoughts

Trust me, once you make this Cheesy Meatball Sub Casserole, it will quickly become a go-to comfort meal that your family and friends rave about. It combines the best parts of familiar flavors in such a simple, fuss-free way that you’ll wonder why you didn’t try it sooner. So grab those ingredients and dive into a casserole experience filled with cheesy, meaty, saucy happiness—you’re going to love every bite!